|
KMID : 0358319960370101080
|
|
Korean Journal of Urology
1996 Volume.37 No. 10 p.1080 ~ p.1086
|
|
|
Prognostic Significance of Bcl-2 Expression in Transitional Cell Carcinoma of the Bladdder
|
|
|
|
|
Abstract
|
|
|
The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell survival by preventing programmed cell death (apoptosis). Recent work has elucidated Bcl-2 expression in many solid tumors including bladder tumor. Because there
exists
some
controversy as to the prognostic significance of Bcl-2 in bladder cancer, we examined the cellular expression of Bcl-2 protein using immunohistochimistry in tumor samples from 89 patients with bladder cancer and determined whether expression of
Bcl-2
has prognostic significance in cancer. We found positive staining for Bcl0-2 (>5% positive cells) in 41 patients (40%). Bcl-2 expression was strongly correlated with tumor stage and grade (superficial vs. invasive, p<0.025; grade II vs. grade
III&IV,
p<0.005). In superficial tumors, Bcl-2 expression was not correlated with diseasefree survival (>0.1) and weakly correlated with progression-free survival (p<0.1). In invasive tumors, Bcl-2 expression was correlated with shortened actuarial
survival
(p<0.025). We assessed the edffect of Bdcl-2 status on the response to chemotherapy or radiotherapy in 25 patients with invasive tumor. The patients with Bcl-2 positive tumors had significantly higher response rate than with Bcl-2 negative tumors
(p<0.05). These results suggest that Bcl-2 protein plays an important role in tumorigenesis of bladder cancer and that Bcl-2 expression is not superior to tumor stage and grade in assessing the prognosis of patients with superficial tumors.
However,
Bcl-2 expression is associated with shortened actuarial survival in the patients with invasive tumor, which may be partly due to chemosensitivity or radiosensitivity in relation to the apoptotic process.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|